San Francisco 49ers vs. Arizona Cardinals Prediction, Preview, and Odds news
Arizona and San Francisco will play in Mexico City on Monday Night Football, pitting a 5-4 Niners squad against a 4-6 Cardinals unit. The 49ers are 3-2 over their past five and
have won consecutive games. The Cardinals are 2-3 over the same span after defeating the Rams last week at home. Kickoff from Estadio Azteca will be at 8:15 pm EDT. San Francisco
is an eight-point spread favorite, and the game total is 43.5 points. San Francisco has a flashy offense and gritty defenseThe 49ers are hot, with consecutive wins over the LA
teams and first place in the NFC West within their reach. San Francisco's offense is legit, with a few star playmakers that attract a lot of attention in Brandon Aiyuk (567
receiving yards and 4 TDs), Deebo Samuel (576 all-purpose yards and 3 TDs), George Kittle (340 receiving yards and 2 TDs), Elijah Mitchell (18 carries for 89 yards vs. LAC), and
Christian McCaffrey (288 all-purpose yards and 3 TDs with SF). Aiyuk, Samuel, and Kittle have been reinvigorated by Mitchell's return from an MCL sprain and McCaffrey's arrival via
trade, giving quarterback Jimmy Garoppolo a stacked deck. Yet, last week versus the Chargers, the defense led the way. San Francisco kept Los Angeles off the scoreboard in the
second half, the second straight game it has done so. Instead of collapsing, SF has rallied since surrendering 44 points to Kansas City in week 8, and the results are clear as
"We know that we're we're one of the best defenses in the league," linebacker Fred Warner said. "We've shown that throughout the season. One bad game doesn't define
This season, the Niners are ranked first in total yards allowed, second in rushing yards allowed, eighth in passing yards allowed, and fourth in points allowed per game.
The defense has tallied 29 sacks, too, led by Nick Bosa (9 sacks and 11 tackles for loss). San Francisco's 26 takeaways rank as the 8th-most in the NFL, as well.
México 🇲🇽(📸 vía @nflmx ) @49ersESP pic.twitter.com/JiVHnuSD7O— San Francisco 49ers (@49ers) November 18, 2022 It's time for Arizona to put up or shut upArizona is
living its worst nightmare with quarterbacks Kyler Murray and Colt McCoy both questionable for Monday Night Football. McCoy started in place of Murray against the Rams last week
and exited the game with a knee injury. No matter who starts under center — ex-Penn State QB Trace McSorley is next in line — Arizona needs them to manage the game with care,
especially against a lockdown San Francisco defense. The 36-year-old McCoy performed admirably in Murray's absence, throwing for 236 yards, including a touchdown pass to A.J.